EC Number   |
Application |
Reference |
|---|
   3.1.3.7 | biotechnology |
GhHL1 is a functional and good candidate gene that might be used to improve salt tolerance in plants |
-, 702183 |
| 3.1.3.7 | medicine |
enzyme as a potential target of lithium therapy |
651264, 651657 |
| 3.1.3.7 | medicine |
mice deficient for bisphosphate 3'-nucleotidase Bpnt1 do not exhibit skeletal defects but instead develop severe liver pathologies, including hypoproteinemia, hepatocellular damage, and in severe cases, frank whole body edema and death. These phenotypes are accompanied by tissue-specific elevations of the substrate 3?-phosphoadenosine 5'-phosphate, up to 50fold in liver, repressed translation, and aberrant nucleolar architecture. The phenotypes of the Bpnt1 knockout are rescued by generating a double mutant mouse deficient for both 3'-phosphoadenosine 5'-phosphate synthesis and hydrolysis, consistent with a mechanism in which 3'-phosphoadenosine 5'-phosphate accumulation is toxic to tissue function independent of sulfation |
730825 |
| 3.1.3.7 | medicine |
the enzyme as a potential target of lithium therapy |
652888 |
| 3.1.3.7 | pharmacology |
the inhibition by lithium suggests the FIG superfamily of enzymes is the target of lithium therapy in manic-depressive illness |
-, 749901 |
| 3.1.3.7 | synthesis |
construction of a protein expression vector using 3',5'-bisphosphate nucleotidase HAL2 in the presence of Ca2+ as an affinity tag. The tag can be used for procaryotic protein expression and purification by maintaining Ca2+ for efficient affinity binding and chelating Ca2+ for elution |
730884 |
