EC Number   |
Application |
Reference |
|---|
   3.1.3.53 | medicine |
Ca2+-desensitizing hypoxic relaxation requires dephosphorylation of myosin phosphatase regulatory subunit |
666160 |
| 3.1.3.53 | medicine |
congestive heart failure is associated with a decrease in the COOH-terminus leucine zipper and the myosin targeting subunit of MLPC expression |
699117 |
| 3.1.3.53 | medicine |
DMBS maintains epithelial integrity, loss of DMBS causes cell shape changes, loss of localization of the apical markers cadherin and increased accumulations of phospho-myosin regulatory light chain and F-actin, DMBS regulates the reorganization of cytoskeleton through down-regulation of myosin II, DMBS fits many of the criteria for a potential neoplastic type tumor suppressor gene |
679422 |
| 3.1.3.53 | medicine |
in response to portal hypertension, abundance of MYPT 1 subunit is significantly reduced and switches to the leucine-zipper positive isoform |
663585 |
| 3.1.3.53 | medicine |
myosin light chain phosphatase pathway is critical in regulating in vivo myofibroblast differentiation during wound healing and fibrocontractive diseases |
-, 683003 |
| 3.1.3.53 | medicine |
MYPT1 is downregulated and switches to the splice variant isoform that codes for the COOH-terminal leucine zipper motif in the hypertension of pregnancy model. These changes in MP expression are prevented by treatment with the antihypertensive medicine hydralazine. Early and effective treatment of hypertension during pregnancy may be able to reverse some of the adverse effects on uterine perfusion and fetal development in this disease |
677461 |
| 3.1.3.53 | medicine |
the expression of isovariants PPP1R12A, PPP1R12BLZ+, PPP1R16A and PPP1R16B mRNA is reduced in late pregnancy (not-in-labor) relative to non-pregnancy. PPP1R12ALZ+ and PPP1R12ALZ- mRNA levels are similar in the non-pregnant and pregnant not-in-labor groups. There is a further reduction in the uterine expression of PPP1R12ALZ+, PPP1R12CLZ+ and PPP1R12ALZ- mRNA with labor relative to the pregnant not-in-labor group. PPP1R12A, PPP1R12BLZ+, PPP1R16A and PPP1R16B mRNA levels are invariant between the not in labor and in-labor groups |
751951 |
| 3.1.3.53 | medicine |
upon induction of congestive heart failure, left ventricular function is reduced to about 30% with concomitant decrease in sensitivity to 8-Br-+cGMP and expression of leucine-zipper positive isoform of MYPT 1 subunit |
664610 |
| 3.1.3.53 | more |
dephosphorylation of myosin regulatory light-chain is essential for rapid recruitment or assembly of myosin II filaments, myosin phosphatase localizes to stress fibers depending on the activity of myosin II ATPase |
-, 681837 |
| 3.1.3.53 | more |
phosphorylation of endogenous inhibitor proteins provides a mechanism for reciprocal coordination of kinase and phosphatase activities |
682882 |
