EC Number |
Application |
Reference |
---|
3.1.11.1 | analysis |
an exonuclease I hydrolysis assay for evaluating G-quadruplex stabilization by small molecules |
682188 |
3.1.11.1 | drug development |
inhibition of a newly synthesized fullerene-oligonucleotide conjugate against PCR-amplification of targeted DNA and the enzymatic activity of an engineered DNA enzyme, Exo I |
696582 |
3.1.11.1 | molecular biology |
Exo1 plays an important role in the induction of apoptosis by unrepaired O6-methylguanines |
-, 701011 |
3.1.11.1 | more |
EXO1 can function as either an exonuclease or flap endonuclease on switch substrates. Model for exonuclease 1 function in class switch recombination, in which cleavage at activation-induced deaminase (AID)-initiated nicks produces gaps that become substrates for further attack by AID and subsequent repair |
700957 |
3.1.11.1 | more |
model for exonuclease 1 function in class switch recombination, in which cleavage at activation-induced deaminase (AID)-initiated nicks produces gaps that become substrates for further attack by AID and subsequent repair |
700957 |
3.1.11.1 | more |
role of BLM and Exo1 in the initiation of recombinational DNA repair. Stimulation of DNA resection by human Exo1 is independent of BLM helicase activity and is, instead, mediated by an interaction between the two proteins. DNA ends resected by Exo1 and BLM are used by human Rad51, but not its yeast or bacterial counterparts, to promote homologous DNA pairing |
700958 |