EC Number |
Application |
Reference |
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2.6.1.52 | diagnostics |
phosphoserine aminotransferase 1 is associated to poor outcome on tamoxifen therapy in recurrent breast cancer |
760151 |
2.6.1.52 | medicine |
hepatic PSAT1 expression and liver serine levels are reduced in genetically engineered leptin receptor-deficient (db/db) mice and high-fat diet (HFD)-induced diabetic mice. Overexpression of PSAT1 by adenovirus expressing PSAT1 improves insulin signaling and insulin sensitivity in vitro and in vivo under normal conditions. Opposite effects are observed when PSAT1 is knocked down by small hairpin RNA specific for PSAT1. Overexpression of PSAT1 also significantly ameliorates insulin resistance in diabetic mice. PSAT1 inhibits the expression of hepatic tribbles homolog TRB3 in vitro and in vivo. Serine mediates PSAT1 regulation of TRB3 expression and insulin signaling in vitro |
738094 |
2.6.1.52 | medicine |
isoform PSAT1 expression is elevated in esophageal squamous cell carcinoma tissues compared to normal esophageal tissues. Increased PSAT1 expression is significantly associated with stage of disease, lymph node metastasis, distant metastasis and poor prognosis. In vitro, PSAT1 overexpression promotes esophageal squamous cell carcinoma cell proliferation and matrigel invasion. In vivo, injection of mice with esophageal squamous cell carcinoma cells overexpressing PSAT1 enhances tumor formation. PSAT1 upregulatesthe expression and/or activity of GSK3beta/Snail |
738015 |
2.6.1.52 | medicine |
promoter hypermethylation and mRNA expression of PSAT1 are indicators of response to tamoxifen-based endocrine therapy in steroid hormone receptorpositive patients with recurrent breast cancer |
672900 |
2.6.1.52 | medicine |
PSAT1 represents a target for colorectal cancer therapy |
705666 |
2.6.1.52 | medicine |
useful for creating a new concept or target for the diagnosis and therapy of human serine metabolism-related disorders and cancer |
640162 |
2.6.1.52 | synthesis |
deletion of L-serine dehydratase in combination with overexpression of enzyme, L-serine insensitive 3-phosphoglycerate dehydrogenase, and phosphoserine phosphatase yields up to 86 mM L-serine in the culture medium |
660769 |