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EC Number Application Commentary Reference
Show all pathways known for 2.5.1.72Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.72drug development te enzyme is required for the biosynthesis of NAD. Besides the de novo pathway for NAD synthesis, a salvage pathway exists in some organisms allowing NAD to be recycled from nicotinic acid and nicotinamide. Some pathogens such as Mycobacterium leprae and Helicobacter pylori lack this salvage pathway. The different pathways for quinolinate biosynthesis in most prokaryotes and eukaryotes, combined with the fact that the salvage pathway is absent in some pathogenic microorganisms, make enzyme NadA an ideal target in the search for specific antibacterial drugs 737716
Show all pathways known for 2.5.1.72Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.72synthesis production of quinolinic acid from L-aspartate, dihydroxyacetone phosphate, and O2 by use of enzymes NadA and NadB 689855
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