EC Number   |
Application |
Reference |
|---|
   2.4.2.6 | medicine |
the low substrate specificity of the enzyme is used advantageously for synthesis of nucleoside analogs, some of them of medical interest |
638050 |
| 2.4.2.6 | synthesis |
compared with NPTs (EC 2.4.2.5), NDTs present the advantage of catalyzing transglycosylation reactions between purine or pyrimidine bases and nucleosides in one enzyme one-pot mode |
-, 759340 |
| 2.4.2.6 | synthesis |
covalent attachment of recombinant Lactobacillus reuteri 2'-deoxyribosyltransferase to Sepabeads EC-EP303. The immobilized enzyme retains 50% of its maximal activity after 17.9 h at 60°C, and 96% activity is observed after storage at 40°C for 110 h. Immobilized enzyme can be recycled for 26 consecutive batch reactions in the synthesis of 2,6-diaminopurine-2'-deoxyriboside with negligible loss of catalytic activity and can be employed in the enzymatic synthesis of different natural and therapeutic nucleosides such as 5-ethyl-2'-deoxyuridine and 5-trifluorothymidine |
721371 |
| 2.4.2.6 | synthesis |
development of a practical method for enzymatic synthesis of deoxyguanosine by the combination of transglycosylation with NdRT-II from thymidine to a 2-amino-6-substituted purine, and the hydrolysis reaction with bacterial adenosine deaminase |
638053 |
| 2.4.2.6 | synthesis |
immobilization of 2'-deoxyribosyltransferase from Lactobacillus reuteri on Sepabeads. Immobilized enzyme activity is enhanced 1.21.4fold at 20% of methanol, ethanol, 2-propanol, diethylene glycol, and acetone, and at 10% and 30% acetonitrile. Highest increased activity is also obtained in presence of 20% acetonitrile. Immobilized enzyme is successfully used in the synthesis of 2'-deoxyxanthosine and 2'-deoxyguanosine using 2'-deoxyuridine as sugar donor and the corresponding poor water-soluble base in the presence of 30% of methanol, ethanol, 2-propanol, ethylene glycol, acetonitrile, and DMSO, giving high nucleoside yields at 4 h |
721851 |
| 2.4.2.6 | synthesis |
potential of LmPDTas an industrial biocatalyst for enzymatic production of several natural and non-natural therapeutic nucleosides, such as vidarabine (ara A), didanosine (ddI), ddG, or 2'-fluoro-2'-deoxyguanosine |
-, 758681 |
| 2.4.2.6 | synthesis |
TbPDT is proficient in the biosynthesis of numerous therapeutic nucleosides, including didanosine, vidarabine, cladribine, fludarabine, and nelarabine. TbPDT has good potential as an industrial biocatalyst for the synthesis of a wide range of therapeutic nucleosides through an efficient and environmentally friendly methodology |
-, 759065 |
| 2.4.2.6 | synthesis |
the enzyme can be used for in-flow synthesis of nucleoside analogues (2'-deoxy, 2',3'-dideoxy and arabinonucleoside derivatives) of pharmaceutical interest in mono- and a bi-enzymatic analytical immobilized enzyme reactors (IMERs), method, overview |
-, 758927 |
| 2.4.2.6 | synthesis |
the enzyme is successfully employed in the enzymatic production of several therapeutic nucleosides such as didanosine, vidarabine, and cytarabine |
-, 758684 |
| 2.4.2.6 | synthesis |
the enzyme is used for a green bioprocess by employing an environmentally friendly methodology to produce floxuridine (5-fluoro-2'-deoxyuridine), a compound with proven anti-tumor activity. The enzyme as enzymatic biocatalyst meets the requirements of high activity, stability, and short reaction times needed for low-cost production in a future preparative application |
-, 759530 |
