EC Number   |
Application |
Reference |
|---|
    2.4.2.10 | diagnostics |
OPRT activity in tumor tissue is a predictor of prognosis in resectable CRC patients treated by oral 5-fluorouracil-based adjuvant chemotherapy, and is useful to pick-up high risk patients independent from known prognosis factors |
674045 |
| 2.4.2.10 | diagnostics |
OPRT and DPD are valuable prognostic markers in gastric cancer |
676267 |
| 2.4.2.10 | medicine |
enzyme activity is 7.5fold enhanced in bladder carcinoma compared to normal. Bladder carcinoma subtypes show distinct levels of enzyme activity and there is positive association between the activity levels of enzyme and thymidylate synthase/thymidine kinase. Enzyme activity in bladder carcinoma cells also correlates positively with their sensitivity to 5-fluorouracil |
658375 |
| 2.4.2.10 | medicine |
immunochemical detection of tumoral enzyme expression by antibody, method for predicting the clinical response to 5-fluorouracil-based chemotherapy |
658935 |
| 2.4.2.10 | medicine |
OPRT activity is significantly lower in tumors with lymph node metastasis than in tumors lacking lymph node metastasis, thus OPRT activity level in tumor tissue may be an important prognostic factor for survival in Dukes B and C colorectal carcinoma cells with radical resection and adjuvant chemotherapy with orally administered tegafur/uracil |
685814 |
| 2.4.2.10 | medicine |
OPRT expression is negatively associated with colorectal cancer progression |
677169 |
| 2.4.2.10 | medicine |
the enzyme is used as a predictor of benefit from S-1 adjuvant chemotherapy for cholangiocarcinoma patients. Cholangiocarcinoma patients with high enzyme expression can benefit from postoperative adjuvant S-1 therapy, which increases the disease-free survival |
759577 |
| 2.4.2.10 | medicine |
the expression of OPRT may be useful to predict the response to adjuvant chemotherapy with 5-fluorouracil in human pancreatic cancer |
689294 |
| 2.4.2.10 | medicine |
the expression of the enzyme shows no association with the overall survival or diseasex1efree survival, even in the patients who receive Sx1e1 adjuvant chemotherapy |
759774 |
| 2.4.2.10 | medicine |
the OPRT mRNA level is positively correlated with the 5-fluorouracil efficacy in antitumor therapy |
684875 |
