EC Number   |
Application |
Reference |
|---|
   2.4.1.87 | diagnostics |
identification of N-acetyllactosamine moiety of glycoproteins and glycolipids by chemiluminescence with mutated enzymes |
707599 |
| 2.4.1.87 | medicine |
application of pig liver for extracorporeal blood circulation in conditions of acute liver failure. GalT knockout hepatocytes and wild-type cells diplay no tumorigenicity. GalT knockout cells show less apoptosis and more viability than wild-type cells when exposed to complement and xenogeneic serum |
758548 |
| 2.4.1.87 | medicine |
development of alpha-1,3-galactosyltransferase (GGTA1) and cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) double-knockout piglets as donor animals for xenotransplantation. Compared to cells from GGTA1-knockout pigs, human antibody binding and antibody-mediated complement-dependent cytotoxicity are significantly reduced in cells from GGTA1/CMAH double-knockout pigs |
745641 |
| 2.4.1.87 | medicine |
Galalpha(1,3)Gal synthesized by iGb3S is immunogenic and elicits antibodies in GGTA1-/- mice. Galalpha(1,3)Gal synthesized by iGb3S may affect survival of pig transplants in humans |
675197 |
| 2.4.1.87 | medicine |
in patients with pretreated metastatic renal cell carcinoma, HyperAcute Renal immunotherapy, i.e. treatment with two allogeneic renal cancer cell lines genetically modified to express alpha(1,3)Gal, is well tolerated and demonstrates antitumor activity |
757885 |
| 2.4.1.87 | medicine |
protection against tumors by immunization with AdaGT-transduced tumor cells (replication deficient adenovirus containing the alpha1,3GT gene) is studied in alpha1,3GT knockout (KO) mice, challenged with the highly tumorigenic BL6 melanoma cells. These mice lack alpha-gal epitopes and can produce anti-Gal. Immunization of KO mice with AdaGT-transduced BL6 cells protects many of the mice against challenge with live BL6 cells lacking alpha-gal epitopes. Immunization with AdalphaGT transduced autologous tumor cells may serve as adjuvant immunotherapy delivered after completion of standard therapy |
672883 |
| 2.4.1.87 | medicine |
the Bacillus thuringiensis phosphatidylinositol-specific phospholipase C and the alpha(1,3)GT genes are engineered to be delivered to cells in two separate retroviral vectors. Activity of phosphatidylinositol-specific phospholipase C, secreted from transduced A549 human lung tumor cells shows a synergistic increase in alphagal mediated complement killing in an in vitro assay. When applied to in vivo therapy of solid tumors, this approach may enhance anti-tumor immune responses |
672885 |
| 2.4.1.87 | synthesis |
- |
489475 |
| 2.4.1.87 | synthesis |
attaching beta p-nitrophenyl to galactose converts the complex from a poor into a good substrate, the group mimics a monosaccharide like N-acetylglucosamine |
707367 |
| 2.4.1.87 | synthesis |
enzymic synthesis of octadecameric saccharides of mutiply branched blood group I-type, carrying 4 distal alpha-1,3-galactose residues |
489475 |
