EC Number   |
Application |
Reference |
|---|
    2.4.1.83 | drug development |
inhibition of DPMS is a promising strategy for the development of anti-trypanosomal agents. Thiazolidinones [(5Z)-5-[[4-(benzyloxy)phenyl]methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid, [(5Z)-5-[[3,4-bis(benzyloxy)phenyl]methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid and [(5Z)-5-[(2-hydroxyphenyl)methylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid in particular are promising candidates for further development because of their respective activities against trypanosomal DPMS and GPI anchor biosynthesis |
702559 |
| 2.4.1.83 | medicine |
D-P-M enzyme activity represents a potentially useful approach to address the problem of porcine endogenous retrovirus infections in clinical xenotransplantations |
706862 |
| 2.4.1.83 | medicine |
increased DPMS activity through protein phosphorylation is a driving force for angiogenesis |
691937 |
| 2.4.1.83 | medicine |
subunits Dpm1 and Dpm3 function as host dependency factors for Dengue virus and other related flaviviruses such as Zika virus. Mutation in the DXD motif of Dpm1, which is essential for its catalytic activity, abolishes DPMS-mediated Dengue virus infection. Genetic ablation of mannosyltransferase ALG3 renders cells poorly susceptible to Dengue virus. In cells deficient for DPMS activity, viral RNA amplification is hampered and truncated oligosaccharides are transferred to the viral precursor of the M protein and E glycoproteins, affecting their proper folding |
757523 |
