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Results 1 - 6 of 6
EC Number Application Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.255analysis application of a high-throughput OGT assay to a library of peptides 736868
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.255analysis metabolic labeling method to introduce the diazirine photocross-linking functional group onto O-GlcNAc residues in mammalian cells. Cells are engineered to produce diazirine-modified UDP-GlcNAc (UDP-Glc-NDAz), which is transferred to substrate proteins by endogenous OGT, producing O-GlcNDAz. Modified proteins can be covalently cross-linked to their binding partners, providing information about O-GlcNAc-dependent interactions 736484
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.255analysis peptide microarray approach to discover novel OGT substrates and study its specificity 737097
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.255analysis single-well OGT enzyme assay that utilizes His6-tagged substrates, a chemoselective chemical reaction, and unpurified OGT. The high-throughput Ni-nitrilotriacetic acid plate OGT assay facilitates discovery of OGT-specific inhibitors on versatile substrates and the characterization of new enzyme variants 735732
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.255medicine pharmacological inhibition of OGT in breast cancer cells has similar anti-growth and anti-invasion effects. OGT may represent novel therapeutic targets for breast cancer 706017
Display the word mapDisplay the reaction diagram Show all sequences 2.4.1.255medicine the neurodegenerative disease protein ataxin-10 (Atx-10) is associated with cytoplasmic OGT p110 in the brain 674603
Results 1 - 6 of 6