EC Number   |
Application |
Reference |
|---|
   2.4.1.155 | biotechnology |
transfection of sense cDNA of enzyme results in increase in the N-acetylglucosamine-beta1,6-mannose-alpha1,3-branch of epidermal growth factor receptor. Transfection with antisense CDNA of enzyme rsults in reverse reaction. Altered expression of enzyme will change the glycan structure and function of epidermal growth factor receptor, which may modify downstream signal transduction |
658420 |
| 2.4.1.155 | diagnostics |
the enzyme is useful as diagnostic marker for gastric adenocarcinomas: low intratumoral MGAT5 density is associated with poor differentiation, N classification, TNM stage, and Kiel stage, and is an independent prognosticator for poor overall survival. The combination of intratumoral MGAT5 expression and TNM or Kiel staging systems has a better predictive power for overall survival. Applying the prognostic value of intratumoral MGAT5 density to TNM stage III+IV and Kiel stage IIIB+IV groups shows a better risk stratification for overall survival in patients with late-stage gastric cancer, overview |
735884 |
| 2.4.1.155 | drug development |
COS may serve as a potential therapeutic candidate for the treatment of metastatic breast cancer |
758997 |
| 2.4.1.155 | medicine |
a selective inhibitor for this GnT-V secretion, a gamma-secretase inhibitor, could provide a useful strategy for the inhibition of tumor angiogenesis and progression |
673512 |
| 2.4.1.155 | medicine |
a simple glycoproteomic strategy to identify the glycoproteins from breast tissue that bind to the lectin L-phytohemagglutinin is developed |
693867 |
| 2.4.1.155 | medicine |
conditional expression of beta1,6GlcNAc-branched N-glycans in postnatal tissues promotes anabolic metabolism and tissue renewal by adapting cellular sensitivities to growth and arrest cues |
692524 |
| 2.4.1.155 | medicine |
enzyme expression is positively related with malignancy in HCC. The enzyme is both a differentiation marker and a potential target for the treatment of hepatocellular carcinoma |
722200 |
| 2.4.1.155 | medicine |
GnT-III transfection into highly pigmented, highly metastatic macrophage-melanoma fusion hybrids resulted in the suppression of both melanogenesis and motility |
688812 |
| 2.4.1.155 | medicine |
GnT-V and beta1-6 branching N-linked oligosaccharide expressions are downregulated during carcinogenesis and progression of human testicular germ cell tumors, GnT-V may be a promising recurrence predictor for stage I non-seminomatous germ cell tumors |
692684 |
| 2.4.1.155 | medicine |
GnT-V expression correlated with a poor prognosis in gastric cancer patients due to metastases |
706072 |
