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Results 1 - 5 of 5
EC Number Application Commentary Reference
Show all pathways known for 2.3.1.94Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.94analysis kinetic assay for the megasynthase that stoichiometrically relates NADPH consumption to polyketide production 736307
Show all pathways known for 2.3.1.94Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.94biotechnology a derivative of Escherichia coli is genetically engineered to produce 6-deoxyerythronolide B, the macrocyclic core of the antibiotic erythromycin 706754
Show all pathways known for 2.3.1.94Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.94biotechnology a new Escherichia coli stain, YW9, is created, featuring a plasmid-free heterologous pathway for the production of the polyketide product 6-deoxyerythronolide B 705513
Show all pathways known for 2.3.1.94Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.94biotechnology polyketide synthases synthesize the polyketide cores of biologically active compounds, including natural products that have become important pharmaceuticals, like erythromycin 706566
Show all pathways known for 2.3.1.94Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.94synthesis the deoxyerythronolide B synthase genes are functionally expressed in Bacillus subtilis when the native eryAI–III operon is separated into three individual expression cassettes with optimized ribosomal binding sites. A synthesis of 6-deoxyerythronolide B can be detected by using the acetoininducible acoA promoter and a fed-batch simulating EnBase-cultivation strategy. Bacillus subtilis is capable of the secretion of 6-deoxyerythronolide B into the medium. The deletion of the prpBD operon of Bacillus subtilis, responsible for propionyl-CoA utilization, results in a significant increase of the 6-deoxyerythronolide B product yield when exogenous propionate is provided 735515
Results 1 - 5 of 5