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EC Number Application Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.164biotechnology Penicillium chrysogenum npe6 lacking isopenicillin N acyltransferase activity is an excellent host for production of different beta-lactam antibiotics 673028
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.164synthesis strategy to improve penicillin biosynthesis by Penicillium chrysogenum by reducing reactive and toxic metabolic byproducts, 2-oxoaldehydes. This is achieved by overexpressing the genes encoding glyoxalase I and II, which results in a 10% increase in penicillin titers relative to the control strain. The protein levels of isopenicillin N synthase and isopenicillin N acyltransferase are increased in the glyoxalase transformants, whereas their transcript levels remains unaltered -, 736734
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