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EC Number Application Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.319medicine modulating PRMT1 activity may represent new avenues to regulate thermogenic fat and mediate energy homeostasis and may ultimately lead to therapeutic strategies against human obesity and associated metabolic disorders 756600
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.319medicine oxidative stress induces apoptosis both via isoform PRMT1 in a SIRT1-dependent manner and via PRMT4 in a SIRT1-independent manner 734831
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.319medicine potential application of PRMT1 inhibitors in cancer treatment 756181
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.319medicine PRMT1 and PRMT5 have opposing effects on chemotherapeutic agent-mediated apoptosis in lung cancer cells. The identification of PRMT5 and PRMT1 as CFLARL regulators involved in cellular apoptosis may help in developing new strategies to increase the sensitivity of cancer cells to chemotherapy, which may eventually benefit lung cancer treatments 757337
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.319medicine splive variant PRMT1 v.2 promotes the survival and invasiveness of breast cancer cells, while it could serve as a biomarker of unfavorable prognosis in colon cancer patients 756861
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