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EC Number	Application	Commentary	Reference
1.5.5.3	medicine	creation of a ProDH2 knock out mouse model. The lack of hydroxyproline dehydrogenase in primary hyperoxalurias mouse models results in lower levels of urinary oxalate excretion. In the double knockout mouse, lacking both glyoxylate reductase/hydroxypyruvate reductase Grhpr and ProDH2, calcium-oxalate crystal deposition in the kidney is prevented, when placed on a 1% hydroxyproline diet	764206
1.5.5.3	medicine	the enzyme is a therapeutic target for the treatment of primary hyperoxaluria	741855

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Release 2023.1 (January 2023)