EC Number   |
Application |
Reference |
|---|
   1.5.1.6 | medicine |
enzyme-induced suppressor effects are strictly dependent on p53 tumor suppressor protein in A549 cells. Enzyme elevation results in p53 phosphorylation at S6 and S20 in the p53 transactivation domain, and S392 in the C-terminal domain, but only S6 is strictly required to mediate enzyme effects |
671840 |
| 1.5.1.6 | medicine |
feeding of ethanol decreases hepatic enzyme activity, decrease occurs irrespective of folate status |
671194 |
| 1.5.1.6 | medicine |
formic acidemia: toxicity of methanol in humans is correlated with formate accumulation as a result of low rates of formate oxidation, which is in vivo dependent on enzyme activity and on hepatic tetrahydrofolate levels |
392340, 392348, 392355 |
| 1.5.1.6 | medicine |
methanol-induced toxicity in Müller cells of the retina, role of 10-FDH in formate intoxination both as a protectant and as a toxicity-provoking element |
392355 |
