EC Number   |
Application |
Reference |
|---|
    1.5.1.2 | medicine |
both PYCR1 mRNA and protein expression are significantly associated with tumor size, grade and invasive molecular subtypes of breast cancers. Higher PYCR1 mRNA levels are significantly associated with poor survival of breast cancer patients, regardless of estrogen receptor status. Inhibition of PYCR1 by small-hairpin RNA significantly reduces the growth and invasion capabilities of the cells, while enhancing the cytotoxicity of doxorubicin in breast cancer cell lines MCF-7 (estrogen receptor positive) and MDA-MB-231 (estrogen receptor negative). Chemotherapy significantly improves survival in early-stage breast cancer patients with low PYCR1 expression levels |
762877 |
| 1.5.1.2 | medicine |
identification of a single homozygous region near the telomere of chromosome 17 in a cohort of patients with cutis laxa type 2. The single nucleotide change leads to a missense mutation adjacent to a slice junction in the gene encoding pyrroline-5-carboxylate reductase 1 which results in exon skipping and leads to deletion of reductase functional domain-coding region and an obligatory downstream frameshift |
695442 |
| 1.5.1.2 | medicine |
mediating apoptosis in tumor cells |
674464 |
| 1.5.1.2 | medicine |
micro-RNA miR-23b*, by targeting POX, may function as an oncogene. Pairs of human renal carcinoma and normal tissues show a negative correlation between miR-23b* and POX protein expression, providing its clinical corroboration. Ectopic overexpression of miR-23b* in normal renal cells results in striking downregulation of POX, whereas POX expression increases markedly when endogenous miR-23b* is knocked down by its antagomirs in renal cancer cells |
713158 |
| 1.5.1.2 | medicine |
overexpression of proline oxidase causes apoptotic cell death in a variety of cancer cells |
672935 |
| 1.5.1.2 | medicine |
proline oxidase can mediate apoptosis through generation of reactive oxygen species |
674605 |
| 1.5.1.2 | medicine |
PYCR1 expression is upregulated in different gastric cancer cohorts. High PYCR1 protein expression is correlated with advanced tumor stage, aggressive histological type and high Ki-67 index. High PYCR1 expression in gastric cancer tissues is an indicator of poor outcome in gastric cancer patients. In vitro, PYCR1 knockdown markedly attenuates gastric cancer cells growth and promoted apoptosis, while overexpression produces the opposite effects. PI3K/Akt axis is strongly correlated with PYCR1 expression and PIK3CB and AKT1 mRNA expression are positively associated with PYCR1 in gastric cancer tissues. PI3K inhibition significantly reduces PYCR1 mRNA and protein expression. Nutrient stress induced by glucose deprivation also regulates PYCR1 expression |
762610 |
| 1.5.1.2 | medicine |
PYCR2 is highly expressed in colorectal cancer patients and high PYCR2 expression is associated with advanced stage, adenocarcinoma, nodal metastasis, and poor survival rate. PYCR2 knockdown reduces cell viability, proliferation, migration, and invasion and increases apoptosis. PYCR2 knockdown increases Bax, cleaved caspase-3, and cleaved PARP levels and decreases Bcl-2, MMP-2, MMP-9, p-PI3K, p-AKT, and p-mTOR levels in colorectal cancer cells |
762952 |
| 1.5.1.2 | medicine |
pyrroline-5-carboxylate reductase is related to virulence of Mycobacterium tuberculosis |
676952 |
