EC Number |
Application |
Reference |
---|
1.3.8.1 | medicine |
newborn screening assays for short-chain acyl-CoA dehydrogenase deficiency are based on the detection of elevated butyrylcarnitine (C4) levels |
689030 |
1.3.8.1 | medicine |
short-chain acyl-coenzyme A dehydrogenase deficiency is attributed to alterations in the SCAD gene |
700228 |
1.3.8.1 | medicine |
short-chain-acyl-CoA-dehydrogenase deficiency is an inborn error of mitochondrial fatty acid metabolism caused by rare mutations as well as common susceptibility variations in the SCAD gene |
689191 |
1.3.8.1 | more |
common variant SCAD enzymes and their potential contribution to clinical disease in humans |
672003 |
1.3.8.1 | more |
development of a novel surface plasmon resonance assay to measure substrate binding |
676021 |
1.3.8.1 | more |
overall high degree of thermodynamic modulation of wild-type SCAD, substrate binding appears to make a larger contribution than does product to thermodynamic modulation, substrate redox activation leading to a large enzyme midpoint potential shift |
672004 |
1.3.8.1 | more |
type I strain has the same clustered genes with the same arrangement as type II strain, deduced amino acid sequences of these enzymes do not greatly differ between the two strains, and even between Butyrivibrio fibrisolvens and clostridia. Amino acid identity appears to be higher within the same type than between types I and II, clustered genes are cotranscribed, and constitutively transcribed without being affected significantly by culture conditions |
668348 |
1.3.8.1 | synthesis |
engineering of Clostridum sp. MT1962 by elimination of phosphotransacetylase and acetaldehyde dehydrogenase along with integration to chromosome synthetic thiolase, 3-hydroxybutyryl-CoA dehydrogenase, crotonase, butyryl-CoA dehydrogenase, butyraldehyde dehydrogenase, and NAD-dependent butanol dehydrogenase. Th resulting strain loses production of ethanol and acetate while initiated the production of 297 mM of n-butanol |
-, 741631 |
1.3.8.1 | synthesis |
expression of acetyl-coenzyme A C-acetyltransferase, 3-hydroxybutyryl-CoA dehydrogenase, crotonase, phosphate butyryltransferase, and butyrate kinase and the butyryl-CoA dehydrogenase complex composed of the dehydrogenase and two electron-transferring flavoprotein subunits as a single plasmid-encoded operon in Escherichia coli to confer butyrate-forming capability |
-, 725287 |