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EC Number	Application	Commentary	Reference
1.3.1.1	analysis	high performance liquid chromatography method for quantification of dihydrouracil to uracil ratio in plasma and application in screening for dihydropyrimidine dehydrogenase deficiency in patients treated with 5-fluorouracil. Plasma dihydrouracil to uracil ratio values are highly correlated with the plasma 5-fluorouracil-half-life values and are significantly associated with the toxic side effects, whereas, data set provided from genetic analysis of the coding sequences of the DPD gene are found to be insufficient to explain all the cases of the 5-fluorouracil-related toxicity pattern. Assay is suitable for routine clinical use for dihydropyrimidine dehydrogenase deficiency assessment in patients prior to 5-fluorouracil administration	700571
1.3.1.1	medicine	dihydropyrimidine dehydrogenase deficiency is known to be a major cause of severe 5-fluorouracil-related toxicity	685850
1.3.1.1	medicine	DPD is a molecular marker for identifying tumor cells sensitivity in breast cancer patients receiving 5-fluorouracil-based chemotherapy	686604
1.3.1.1	medicine	target for inhibitor design to enhance the cytotoxical effect of 5-fluorouracil in tumor cells by inhibiting the DPD activity with 5-fluorouracil as substrate	349142, 349143

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Release 2023.1 (January 2023)