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EC Number Application Commentary Reference
Show all pathways known for 1.2.1.4Display the word mapDisplay the reaction diagram Show all sequences 1.2.1.4medicine ALDH3A1 contributes to the detoxification of various aldehydes produced in response to oxidative stress 673477
Show all pathways known for 1.2.1.4Display the word mapDisplay the reaction diagram Show all sequences 1.2.1.4synthesis the aldehyde dehydrogenase from Thermoplasma acidophilum implemented as a key enzyme in a synthetic cellfree reaction cascade for the production of alcohols. Thermoplasma acidophilum enzyme TaALDH matches the cascade equirements regarding temperature stability, efficient heterologous expression in Escherichia coli, and exclusive activity for D-glyceraldehyde (not active on acetaldehyde). The remaining drawback is its cofactor preference toward NADP+ resulting in high KM for NAD+ and a rather low overall activity under cascade conditions -, 762562
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