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EC Number Application Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 1.14.18.6medicine in blood and fibroblasts from patients harboring a deleterious FA2H mutatation, hydroxylated fatty acid sphingomyelin is present in normal amounts in patient lymphocytes, but decreases to a different extent in fibroblasts and erythrocytes 734599
Display the word mapDisplay the reaction diagram Show all sequences 1.14.18.6medicine silencing of sphingolipid fatty acyl 2-hydroxylase Fa2h turns the cells resistant to synthetic antitumor drug PM02734, i.e. elisidepsin. Overexpression of Fa2H leads to an increased sensitivity to PM02734. Exogenous addition of the 2-hydroxylated fatty acid 2-hydroxy palmitic acid to different human cell lines increases their sensitivity to the cytotoxic compound 733604
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