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EC Number Application Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 1.11.2.2analysis detection of myeloperoxidase activity in vivo by use of a paramagneitc substrate. The sensing probe is obtained by replacing the reducing substrate serotonin with 5-hydroxytryptophan. The resulting probe bis-hydroxytryptophan-gadolinium diethylenetriamine pentaacetic acid in vitro improves solubility in water, acts as a substrate, induces cross linking of proteins in the presence of myeloperoxidase,produces oxidation products which bind to plasma proteins and does not follow first order reaction kinetics. Bis-hydroxytryptophan-gadolinium diethylenetriamine pentaacetic acid is retained for up to five days in myeloperoxidase-containing sites and cleared faster than serotonin diethylenetriamine pentaacetic acid from enzyme-negative sites 725986
Display the word mapDisplay the reaction diagram Show all sequences 1.11.2.2medicine loading macrophages with exogenous myeloperoxidase could enhance their microbicidal activity, potentially useful therapeutic application 661675
Display the word mapDisplay the reaction diagram Show all sequences 1.11.2.2medicine the enzyme is an interesting target for anti-inflammatory therapy 671909
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