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Results 1 - 6 of 6
EC Number
Application
Commentary
Reference
degradation
MMP-20 processes dentin sialophosphoprotein into smaller subunits in the dentin matrix during odontogenesis
medicine
critical role of MMPs in the processing and maturation of the dental matrix
medicine
first report of a homozygous mutation in the MMP-20 gene, the mutation destroys the splice acceptor sequence at the 3' end of intron 6 encoding the hemopexin domain, the enamel of the subjects' teeth is pigmented, its surface mottled and rough and the enamel layer more opaque than the underlying dentine
more
MMP-20 acts either directly or indirectly to faciliate the removal of maturation-stage enamel proteins
more
MMP-20 expression is primarly confined to tooth tissue
pharmacology
enzyme is a potential target for selective inhibition and inhibitor design
Results 1 - 6 of 6