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local tissue damage after snakebite, causes hemorrhage followed by myonecrosis and arterial necrosis after intramuscular injection of doses of 0.02 mg in mice, myonecrosis is still observed with lower doses down to 0.001 mg
secretory cells of venom gland can be a good in vitro apparatus to produce venom, assemblage of isolated cells into acini that grow in size up to 21 days, instead of adhering to the substrate, source for all pharmacological and biotechnological studies, as well as providing an improved avenue for treatments of snakebites, venom detection and quantification after 2 weeks only in culture devoid of Bothrops jararaca serum
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