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Results 1 - 6 of 6
EC Number
Application
Commentary
Reference
analysis
ARPE-19 cell system is appropriate for studying the visual cycle enzymes
diagnostics
enzyme might be a prognostic or therapeutic marker in renal cancer
diagnostics
the Lrat knockout mutant mice may serve as animal model with early onset severe retinal dystrophy and severe retinyl ester deprivation
medicine
expression of RPE65 involved in vitamin A metabolism is downregulated in malignant melanoma compared with benign melanocytic nevi. In contrast, expression of LRAT is not significantly different. High LRAT expression in melanoma metastases is inversely correlated with patient survival, Kaplan-Meier analysis reveals earlier melanoma-related death
medicine
LRAT mutations are likely a rare cause of Leber congenital amaurosis among patients from North America
medicine
study on the effects of ectopic expression of human lecithin:retinol acyltransferase on murine oral cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide. In transgenic mice with targeted human LRAT expression to the basal layer of mouse skin and oral cavity epithelia, the retinyl ester levels in skin are 32% greater than those in wild-type mice, and topical treatment of the back skin with retinol results in greater increases in retinyl esters than in wild-type mouse skin. While 4-nitroquinoline 1-oxide treatment induces multifocal precancerous and cancer lesions in the tongues of both transgene positive and negative mice, higher percentages of transgene positive mice develop more severe tongue lesions of grades 3 and 4 than transgene negative mice after 4-nitroquinoline 1-oxide treatment. Carcinogen treatment also results in greater percentages of transgene positive mouse tongues with hyperplasia, dysplasia, and carcinoma than transgene negative mouse tongues. There are higher cyclooxygenase-2 and lower RARbeta(2) mRNA levels in transgene positive mouse tongues as compared to wild-type mouse tongues after 4-nitroquinoline 1-oxide treatment
Results 1 - 6 of 6