EC Number   |
Application  |
Reference |
|---|
   1.3.99.23 | analysis |
the mouse pluripotent P-19 cell metabolizes retinol to atRA and thus can be used in a cell-based screen for disruptors of the pathway. The disruption of the pathway is easily detected and quantitated, the P-19 cell provides an in vitro model system for identifying and exploring the mechanism of action of chemicals that interfere with the critical cellular pathway |
725598 |
| 1.3.99.23 | medicine |
enzyme RetSat is a critical regulator of liver metabolism functioning upstream of ChREBP. Pharmacological inhibition of liver RetSat may represent a therapeutic approach for steatosis |
763507 |
| 1.3.99.23 | medicine |
RetSat plays an important role in the biology of adipocytes, where it favors normal differentiation, yet is reduced in the obese state, RetSat is thus a novel target for therapeutic intervention in metabolic disease |
700994 |
| 1.3.99.23 | more |
conserved function but altered specificity of RetSat in vertebrates |
672228 |
