EC Number   |
Application  |
Reference |
|---|
   1.10.5.1 | medicine |
an increased risk of breast cancer is associated with the NQ2 I-29 allele. The I-29-containing genotype is significantly correlated with breast cancer under a dominant model. There is a significant association of the I-29/D polymorphism with luminal-like breast cancer but not with HER2-enriched or triple-negative subtypes |
764726 |
| 1.10.5.1 | medicine |
anti-cancer therapy |
671708 |
| 1.10.5.1 | medicine |
estrogen quinones, including estradiol estradiol-3,4-quinone, generated by estrogen metabolism, are thought to be responsible for estrogen-initiated carcinogenesis. NQO2 could be a novel target for prevention of breast cancer initiation |
698051 |
| 1.10.5.1 | medicine |
NQO2 protein level is significantly higher in non-small cell lung cancer tissues as compared with their normal tissues. NQO2 score at clinical stages III and IV is higher than stage I, and there exists a significant correlation between tumor NQO2 expression level and the pathologic T stage |
763861 |
| 1.10.5.1 | medicine |
QR2 inhibitors possibly represent a therapeutic strategy toward the treatment of learning deficits especially observed in the aged brain |
712829 |
| 1.10.5.1 | medicine |
quinone reductase 2 can play important roles in the regulation of catecholamine oxidation processes that may be involved in the etiology of Parkinson disease |
698793 |
| 1.10.5.1 | medicine |
the high NQO2 activity of intraperitoneal ovarian metastases relative to other tissues indicates a potential for tretazicar therapy in the treatment of this disease |
686136 |
