EC Number   |
Natural Substrates |
|---|
    6.4.1.1 | ATP + pyruvate + HCO3- |
- |
| 6.4.1.1 | ATP + pyruvate + HCO3- |
anaplerotic enzyme |
| 6.4.1.1 | ATP + pyruvate + HCO3- |
anaplerotic enzyme for growth on carbohydrates, reaction is a major bottleneck for amino acid production |
| 6.4.1.1 | ATP + pyruvate + HCO3- |
cells containing the enzyme yield significantly more cell mass while generating less acetate |
| 6.4.1.1 | ATP + pyruvate + HCO3- |
essential for normal growth |
| 6.4.1.1 | ATP + pyruvate + HCO3- |
role in gluconeogenesis, lipogenesis, biosynthesis of neurotransmitter substances and in glucose-induced insulin secretion by pancreatic islets |
| 6.4.1.1 | ATP + pyruvate + HCO3- |
role of anaplerosis in the central carbon metabolism and amino acid synthesis |
| 6.4.1.1 | ATP + pyruvate + HCO3- |
Pyc1 and Pyc2 display different allosteric properties with respect to acetyl CoA activation and aspartate inhibition, with Pyc1 showing a higher degree of cooperativity than Pyc2, even in the absence of aspartate |
| 6.4.1.1 | ATP + pyruvate + HCO3- |
pyruvate carboxylase, and thereby anaplerosis, is crucial for an appropriate rise in the ATP:ADP ratio in response to fuel metabolism |
| 6.4.1.1 | ATP + pyruvate + HCO3- |
the catalyzed anaplerotic reaction is very important replenishing oxaloacetate withdrawn from the tricarboxylic acid cycle for various pivotal biochemical pathways, overview |
