EC Number   |
Natural Substrates |
|---|
    6.3.4.3 | ADP + phosphate + 10-formyltetrahydrofolate |
ATP production. The relative concentration of formylated and unformylated folate coenzymes may be a significant regulatory parameter in the purine-fermenting Clostridia |
| 6.3.4.3 | ATP + formate + tetrahydrofolate |
- |
| 6.3.4.3 | ATP + formate + tetrahydrofolate |
FtfL activity is required for methylotrophic growth |
| 6.3.4.3 | ATP + formate + tetrahydrofolate |
flow of one-carbon units through cytoplasmic and mitochondrial folate pathways, overview |
| 6.3.4.3 | ATP + formate + tetrahydrofolate |
enzyme of one-carbon metabolism |
| 6.3.4.3 | ATP + formate + tetrahydrofolate |
two different physiological roles: 1. Functions anabolically in most organisms to activate formate via the forward reaction, and brings it into the one-carbon metabolic pool as N10-formyltetrahydrofolate, 2. In purine-fermenting bacteria the enzyme probably functions catabolically in the terminal step of the purine degradative pathway. This reaction may be responsible for ATP production in these organisms |
| 6.3.4.3 | ATP + formate + tetrahydrofolate |
the trifunctional enzyme is involved in the interconversion of one-carbon adducts of tetrahydrofolate |
| 6.3.4.3 | ATP + formate + tetrahydrofolate |
the enzyme is responsible for the recruitment of single carbon units from the formate pool into a variety of folate-dependent biosynthetic pathways |
| 6.3.4.3 | ATP + formate + tetrahydrofolate |
rate-determining step in the conversion of formate to Ser |
| 6.3.4.3 | formate + ATP + tetrahydrofolate |
synthetase activity of MTHFD1 |
