EC Number |
Natural Substrates |
---|
6.3.2.4 | ATP + 2 D-alanine |
- |
6.3.2.4 | ATP + Ala + Ala |
second enzyme in the three enzyme D-alanine branch of peptidoglycan biosynthesis |
6.3.2.4 | ATP + Ala + Ala |
enzyme involved in peptidoglycan precursor synthesis during sporulation |
6.3.2.4 | ATP + Ala + Ala |
a possible cellular role of VanA is to synthesize a modified cell-wall component, with D-Ala-D-Met or D-Ala-Phe instead of D-Ala-D-Ala, which is subsequently not recognized by vancomycin |
6.3.2.4 | ATP + Ala + Ala |
the finding that the reactions of EC 6.3.2.4 and EC 6.3.2.10 are reversible may represent a functional regulatory mechanism which determines the level of the lysine-containing UDPMurNAc-pentapeptide depending on the intracellular ATP/ADP ratio |
6.3.2.4 | ATP + Ala + Ala |
one step in peptidoglycan synthesis: the formation of D-Ala-D-Ala, the terminal dipeptide of the UDP-N-acetylmuramylpentapeptide |
6.3.2.4 | ATP + Ala + Ala |
second step in the biosynthesis of bacterial peptidoglycan |
6.3.2.4 | ATP + D-alanine |
- |
6.3.2.4 | ATP + D-alanine |
essential enzyme |
6.3.2.4 | ATP + D-alanine |
D-alanine:D-alanine ligase is an essential enzyme in bacterial cell wall biosynthesis and an important target for developing new antibiotics |