EC Number |
Natural Substrates |
---|
6.3.2.17 | ATP + methotrexate + L-glutamate |
- |
6.3.2.17 | ATP + tetrahydrofolate-Glu + L-glutamate |
- |
6.3.2.17 | ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate |
- |
6.3.2.17 | more |
enzyme catalyzes the addition of glutamate residues to folates and antifolates to form the physiological active coenzymatic forms of the vitamin and more potent anti-folate agents |
6.3.2.17 | more |
enzyme in biosynthesis of folylpolyglutamates , the most universal functions of folylpolyglutamates: 1. Actual cofactors in vivo for folate dependent enzymes, 2. Inhibitor of folate dependent enzymes for which they are not substrates, 3. Increases retention of folates after they are transported into cells as monoglutamates |
6.3.2.17 | more |
mitochondrial enzyme is required for mitochondrial one carbon metabolism and for normal one carbon flux in the cytosol |
6.3.2.17 | more |
enzyme of folate biosynthetic pathway |
6.3.2.17 | more |
central enzyme in establishing and maintaining folylpolyglutamate pools in whole cells |
6.3.2.17 | more |
the enzyme catalyzes the consecutive addition of one or more L-glutamyl moieties to the gamma-carboxyl group in natural folates and glutamate-containing antifolates. Cells deficient in this enzyme are auxothrophic for thymidine and a purine |
6.3.2.17 | more |
the enzyme catalyzes the formation of an amide bond between glutamic acid and the gamma-carboxyl group of any of the naturally occurring folate compounds |