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Results 1 - 10 of 16 > >>
EC Number Natural Substrates Commentary (Nat. Sub.)
Show all pathways known for 6.3.2.17Display the word mapDisplay the reaction diagram Show all sequences 6.3.2.17ATP + methotrexate + L-glutamate -
Show all pathways known for 6.3.2.17Display the word mapDisplay the reaction diagram Show all sequences 6.3.2.17ATP + tetrahydrofolate-Glu + L-glutamate -
Show all pathways known for 6.3.2.17Display the word mapDisplay the reaction diagram Show all sequences 6.3.2.17ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate -
Show all pathways known for 6.3.2.17Display the word mapDisplay the reaction diagram Show all sequences 6.3.2.17more enzyme catalyzes the addition of glutamate residues to folates and antifolates to form the physiological active coenzymatic forms of the vitamin and more potent anti-folate agents
Show all pathways known for 6.3.2.17Display the word mapDisplay the reaction diagram Show all sequences 6.3.2.17more enzyme in biosynthesis of folylpolyglutamates , the most universal functions of folylpolyglutamates: 1. Actual cofactors in vivo for folate dependent enzymes, 2. Inhibitor of folate dependent enzymes for which they are not substrates, 3. Increases retention of folates after they are transported into cells as monoglutamates
Show all pathways known for 6.3.2.17Display the word mapDisplay the reaction diagram Show all sequences 6.3.2.17more mitochondrial enzyme is required for mitochondrial one carbon metabolism and for normal one carbon flux in the cytosol
Show all pathways known for 6.3.2.17Display the word mapDisplay the reaction diagram Show all sequences 6.3.2.17more enzyme of folate biosynthetic pathway
Show all pathways known for 6.3.2.17Display the word mapDisplay the reaction diagram Show all sequences 6.3.2.17more central enzyme in establishing and maintaining folylpolyglutamate pools in whole cells
Show all pathways known for 6.3.2.17Display the word mapDisplay the reaction diagram Show all sequences 6.3.2.17more the enzyme catalyzes the consecutive addition of one or more L-glutamyl moieties to the gamma-carboxyl group in natural folates and glutamate-containing antifolates. Cells deficient in this enzyme are auxothrophic for thymidine and a purine
Show all pathways known for 6.3.2.17Display the word mapDisplay the reaction diagram Show all sequences 6.3.2.17more the enzyme catalyzes the formation of an amide bond between glutamic acid and the gamma-carboxyl group of any of the naturally occurring folate compounds
Results 1 - 10 of 16 > >>