EC Number |
Natural Substrates |
---|
6.3.1.9 | 2 glutathione + spermidine + 2 ATP |
important reaction in defense against chemical and oxidant stress, thiol redox homeostasis, ribonucleotide metabolism, and drug resistance in parasitic kinetoplastids |
6.3.1.9 | 2 glutathione + spermidine + 2 ATP |
trypanothione synthase overall reaction |
6.3.1.9 | 2 glutathione + spermidine + 2 ATP |
trypanothione synthase overall reaction, trypanothione metabolism overview |
6.3.1.9 | 2 glutathione + spermidine + 2 ATP |
overall reaction, the enzyme catalyzes the formation of N1,N8-bis(glutathionyl)spermidine in two reaction steps, exhibiting activity of EC 6.3.1.8, glutathionylspermidine synthase, and 6.3.1.9, trypanothione synthase |
6.3.1.9 | 2 glutathione + spermidine + 2 ATP |
overall reaction, the enzyme catalyzes the formation of N1,N8-bis(glutathionyl)spermidine in two reaction steps, exhibiting activity of EC 6.3.1.8, glutathionylspermidine synthase, and 6.3.1.9, trypanothione synthase, overview |
6.3.1.9 | gamma-L-Glu-L-Cys-Gly + N1-(gamma-Glu-L-Cys-Gly)-spermidine + ATP |
synthesis of trypanothione, which is involved in maintaining intracellular thiol redox and in defense against oxidants |
6.3.1.9 | gamma-L-Glu-L-Cys-Gly + N1-(gamma-Glu-L-Cys-Gly)-spermidine + ATP |
the enzyme is involved in the biosynthesis of the trypanosomatid-specific dithiol trypanothione |
6.3.1.9 | gamma-L-glutamyl-L-cysteinyl-glycine + N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + ATP |
- |
6.3.1.9 | glutathione + glutathionylspermidine + ATP |
- |
6.3.1.9 | glutathione + glutathionylspermidine + ATP |
trypanothione synthase catalyzes both the reaction of glutathionylspermidine synthase, EC 6.3.1.8, and of trypanothione synthase, EC 6.3.1.9, in Trypanosoma brucei |