EC Number   |
Natural Substrates |
|---|
    6.2.1.30 | ATP + butyric acid + CoA |
- |
| 6.2.1.30 | ATP + phenylacetate + CoA |
- |
| 6.2.1.30 | ATP + phenylacetate + CoA |
phenylacetate-CoA ligase is involved in penicillin production. The enzyme lacks a peptidyl carrier and behaves as an aryl-capping enzyme that activates phenylacetic acid and transfers it to the isopenicillin N acyltransferase. It is proposed that phenylacetate-CoA ligase and isopenicillin N-acyltransferase form a peroxisomal functional complex |
| 6.2.1.30 | ATP + phenylacetate + CoA |
PhlB might participate in the activation of phenylacetic acid during penicillin biosynthesis in Penicillium chrysogenum |
| 6.2.1.30 | ATP + phenylacetate + CoA |
the phenylacetyl-CoA ligase encoded by the phl gene is involved in penicillin production. The Phl protein lacks a peptide-carrier-protein domain and behaves as an aryl-capping enzyme that activates phenylacetic acid and transfers it to the isopenicillin N acyltransferase |
| 6.2.1.30 | ATP + phenylacetate + CoA |
enzymatic activation of phenylacetic acid to phenylacetyl-CoA is an important step in the biosynthesis of the beta-lactam antibiotic penicillin G by the fungus Penicillium chrysogenum, CoA esters of phenylacetic acid and phenoxyacetic acid act as acyl donor in the exchange of the aminoadipyl side chain of isopenicillin N to produce penicillin G or penicillin V |
| 6.2.1.30 | ATP + phenylacetate + CoA |
phenylacetate-CoA ligase catalyzes the inital step of phenylacetate metabolism in the organism |
| 6.2.1.30 | ATP + phenylacetate + CoA |
the first step of this phenylacetate degradation pathway is catalysed by paaF-encoded phenylacetyl-CoA ligases that produce phenylacetyl-CoA |
| 6.2.1.30 | ATP + phenylacetate + CoA |
enzyme is involved in the catabolism of phenylacetic acid |
| 6.2.1.30 | ATP + phenylacetate + CoA |
first step in anaerobic degradation pathway of phenylacetate |
