EC Number   |
Natural Substrates |
|---|
    6.2.1.17 | ATP + 3-hydroxypropanoate + CoA |
- |
| 6.2.1.17 | ATP + 3-hydroxypropionate + CoA + NADPH |
involved in CO2 fixation via 3-hydroxypropionate cycle |
| 6.2.1.17 | ATP + propanoate + CoA |
- |
| 6.2.1.17 | ATP + propanoate + CoA |
required for propionate catabolism |
| 6.2.1.17 | ATP + propanoate + CoA |
required for propionate catabolism, recapture of exogenous propionate |
| 6.2.1.17 | ATP + propanoate + CoA |
propionyl-CoA is a potent precursor of epothilone B, a potential anti-cancer agent |
| 6.2.1.17 | ATP + propanoate + CoA |
propanoate resulting from the terminal oxidation of propane to 1-propanol and oxidation of 1-propanol via the propanal dehydrogenase may be further metabolized via propanoyl-CoA synthetase |
| 6.2.1.17 | ATP + propanoate + CoA |
intracellular accumulation of propanoyl-CoA is associated with impairment of important heptic metabolic pathways. Since propanoate absorbed from the intestine can be converted to propanoyl-CoA in the liver, inhibition of propanoyl-CoA synthesis from propanoate and CoA may provide a strategy for decreasing toxicity from plasma propanoate |
| 6.2.1.17 | ATP + propanoate + CoA |
the distinct propionyl CoA synthetase regulated by the concentration of propanoate in portal blood is significant because a primary role of ruminant liver is to synthesize glucose from ruminally derived propanoate |
| 6.2.1.17 | more |
activates volatile fatty acids |
