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EC Number
Natural Substrates
Commentary (Nat. Sub.)
6.2.1.16
ATP + acetoacetate + CoA
-
6.2.1.16
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primary role of acetoacetate as a substrate in lipogenesis is to promote cholesterol biosynthesis. Regulation of acetoacetyl-CoA synthetase is synchronized with the regulation of cholesterol biosynthesis
6.2.1.16
more
enzyme normally functions in the re-utilization of some of the acetoacetate produced within the mitochondrion as well as that reaching the cytoplasm
6.2.1.16
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AACS in adipose tissue plays an important role in utilizing ketone bodies for the fatty acid-synthesis during adipose tissue development
6.2.1.16
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AACS promoter activity is controlled mainly by C/EBP? during adipogenesis
6.2.1.16
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SlAacS is a bona fide acetoacetyl-CoA synthetase, an AMP-forming acyl-CoA synthetase
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