EC Number   |
Natural Substrates |
|---|
    6.1.1.21 | ATP + L-histidine + tRNAHis |
- |
| 6.1.1.21 | ATP + L-histidine + tRNAHis |
phylogenetic and evolutionary development |
| 6.1.1.21 | ATP + L-histidine + tRNAHis |
the enzyme is involved in several regulatory mechanisms of the cell metabolism |
| 6.1.1.21 | ATP + L-histidine + tRNAHis |
strong association of autoantibodies, specificity recognizing the enzyme's granzyme B binding site of the lung enzyme, to HisRS with interstitial lung disease in patients with myositis |
| 6.1.1.21 | more |
1. plays an important role in the regulation of protein degradation as well as in protein biosynthesis. 2. involvement of tRNAHis and possibly histidyl-tRNA synthetase in a nonlysosomal ubiquitin-dependent and ATP-dependent protein degradation pathway. 3. involvement in autoimmune diseases |
| 6.1.1.21 | more |
determination of enzyme-induced chemotactic activity of human cells, e.g. leukocytes and primary neutrophils, to the enzyme |
| 6.1.1.21 | more |
the enzyme can act as an important antigen in autoimmune diseases such as rheumatic arthritis or myositis |
| 6.1.1.21 | more |
Caulobacter crescentus HisRS shows very low activity with Escherichia coli tRNAHis |
