EC Number   |
Natural Substrates |
|---|
    6.1.1.2 | ATP + L-tryptophan + tRNATrp |
- |
| 6.1.1.2 | ATP + L-tryptophan + tRNATrp |
activity and fidelity are essential for viability |
| 6.1.1.2 | ATP + L-tryptophan + tRNATrp |
enzyme contributes to biological processes involving cell signaling such as angiogenesis regulation |
| 6.1.1.2 | ATP + L-tryptophan + tRNATrp |
enzyme is required for embryonic survival, and is essential for viability of the fly |
| 6.1.1.2 | ATP + L-tryptophan + tRNATrp |
full-length and mini enzyme isoforms, enzyme expression is regulated by a dual system of interferon gamma and interferon regulatory factor 1 via 2 specific tandem promoters leading to alternative splicing |
| 6.1.1.2 | ATP + L-tryptophan + tRNATrp |
both TrpRS1 and TrpRS2 are essential for growth and required for cytosolic and mitochondrial tryptophanyl-tRNA formation, respectively, the edited anticodon and the mitochondria-specific thiolation of U33 in the imported tRNATrp act as antideterminants for the cytosolic TrpRS1, the mitochondrion of Trypanosoma brucei does not encode any tRNAs, this deficiency is compensated for by the import of a small fraction of nearly all of its cytosolic tRNAs from the host |
| 6.1.1.2 | ATP + L-tryptophan + tRNATrp |
involvement of heme in regulation of TrpRS aminoacylation activity |
| 6.1.1.2 | ATP + L-tryptophan + tRNATrp |
the enzyme is essential for translation |
| 6.1.1.2 | more |
- |
| 6.1.1.2 | more |
possibly involved in function other than tRNA aminoacylation |
