EC Number |
Natural Substrates |
---|
6.1.1.11 | ATP + L-serine + tRNASec |
SerRS also aminoacylates tRNASec with serine as the first step for the incorporation of selenocysteine into proteins, SerRS is essential for growth Trypanosoma brucei and is responsible for the serylation of both tRNASer and tRNASec |
6.1.1.11 | ATP + L-serine + tRNASec |
SerRS also aminoacylates tRNASec with serine as the first step for the incorporation of selenocysteine into proteins, SerRS is responsible for the serylation of both tRNASer and tRNASec |
6.1.1.11 | ATP + L-serine + tRNASer |
- |
6.1.1.11 | ATP + L-serine + tRNASer |
tRNASer from Escherichia coli |
6.1.1.11 | ATP + L-serine + tRNASer |
gene silencing of the Nicotiana benthamiana SerRS causes severe leaf yellowing and abnormal leaf morphology, while maintaining almost normal plant growth. At the cell level depletion of the NcSRS gene results in dramatically reduced numbers of chloroplasts with reduced sizes and chlorophyll content. The numbers and/or physiology of mitochondria are also severely affected. The abnormal chloroplasts lack most of the thylakoid membranes and appear to be degenerating, whereas some of them show doublet morphology, indicating defective chloroplast division |
6.1.1.11 | ATP + L-serine + tRNASer |
responsible for the serylation of both tRNASer and tRNASec |
6.1.1.11 | ATP + L-serine + tRNASer |
tRNASec, unlike most trypanosomal tRNAs, is exclusively localized in the cytosol, SerRS is essential for growth Trypanosoma brucei and is responsible for the serylation of both tRNASer and tRNASec |
6.1.1.11 | more |
catalyzes the binding of 4-hydroxyaminoquinoline 1-oxide (a reduced metabolite of the carcinogenic and mutagenic compound 4-nitroquinoline 1-oxide) to nucleic acid. Seryl-tRNA synthetase may participate in vivo in the activation of some N-hydroxy compounds through their aminoacylation capacity |
6.1.1.11 | more |
high abundance in middle silk gland may result from an adaption of this organ for the production of the serine-rich protein, sericin |
6.1.1.11 | more |
phylogenetic comparison |