EC Number   |
Natural Substrates |
|---|
   5.6.1.6 | ATP + H2O + closed Cl- channel |
- |
| 5.6.1.6 | ATP + H2O + closed Cl- channel |
coupling between ATP hydrolysis and chloride channel gating |
| 5.6.1.6 | ATP + H2O + closed Cl- channel |
EBCR is involved in hormone-regulated chloride reabsorption |
| 5.6.1.6 | ATP + H2O + closed Cl- channel |
CFTR function in epithelial cells is regulated by an interplay between syntaxin and Munc18 isoforms |
| 5.6.1.6 | ATP + H2O + closed Cl- channel |
syntaxin 1A limits the functional activities of normal and disease-associated forms of the chloride channel |
| 5.6.1.6 | ATP + H2O + closed Cl- channel |
CFTR appears to be important both as a HCO3- conductance and also in some way as a direct or indirect regulator of adjacent anion exchange, e.g. as a source of luminal Cl- that may exchange for cellular HCO3- and/or as a means of keeping cellular Cl- concentration low enough that the anion exchanger operates as an HCO3- secretion mechanism |
| 5.6.1.6 | ATP + H2O + closed Cl- channel |
enzyme is regulated by cAMP |
| 5.6.1.6 | ATP + H2O + closed Cl- channel |
small-conductance chloride channel, direct coupling between cellular ATP levels and chloride channel activity may be an adaptive mechanism to protect the tissue from damage resulting from excessive energy depletion |
| 5.6.1.6 | ATP + H2O + closed Cl- channel |
can function as a chloride-selective anion channel, may also play a role in regulation of the membrane vesicle trafficking and fusion, acidification of organelles and transport of small anions |
| 5.6.1.6 | ATP + H2O + closed Cl- channel |
CFTR is a conductance regulator as well as a Cl- channel, CFTR regulates other ion channel proteins |
