EC Number   |
Natural Substrates |
|---|
   5.2.1.8 | AGL24 protein |
cis/trans conformational change of phosphorylated Ser/Thr-Pro motif. The interaction between Pin1At and AGL24 mediates the AGL24 stability in the nucleus |
| 5.2.1.8 | amyloidbeta precursor protein |
interaction with Thr688 |
| 5.2.1.8 | colicin M |
- |
| 5.2.1.8 | hepatitis C virus NS5A protein |
nonstructural 5A protein, NS5A, from the JFH1 hepatitis C virus strain. Mutations in this domain are linked to cyclosporin A resistance |
| 5.2.1.8 | interleukin-2 tyrosine kinase |
catalytic activity of interleukin-2 tyrosine kinase is inhibited by peptidylprolyl isomerase activity of cyclophilin A. Proline-dependent conformational switch within the interleukin-2 tyrosine kinase SH2 domain regulates substrate recognition and mediates regulatory interactions with the active site of cyclophilin A |
| 5.2.1.8 | more |
- |
| 5.2.1.8 | more |
the presence of cyclophilin A in the human immunodeficiency virus type 1, HIV-1, is required for HIV-1 to infect and replicate |
| 5.2.1.8 | more |
the enzyme is essential for protein folding during protein synthesis and may be involved in events, such as those occuring early in T-cell activation |
| 5.2.1.8 | more |
the functional role may involve signal transduction of specific genes essential for T-lymphocyte activation and proliferation |
| 5.2.1.8 | more |
the folding of some exported proteins may be catalyzed by the periplasmic proline isomerase |
