EC Number   |
Natural Substrates |
|---|
   4.6.1.18 | more |
enzyme expressed in K-562 cell is cytotoxic and cytostatic, IC50 value 0.0009 mM |
| 4.6.1.18 | more |
enzyme is both angiogenic and bactericidal. Domains II, amino acids 71-76, and III, amino acids 89-104, of RNase A-2 are both important for bactericidal activity |
| 4.6.1.18 | more |
isoform RNase1 is bactericidal with potent activities against the gramnegative bacteria Escherichia coli and Pseudomonas aeruginosa but only mild effects against the gram-positive bacteria Staphylococcus aureus |
| 4.6.1.18 | more |
isoform RNase2 is bactericidal with potent activities against the gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa but only mild effects against the gram-positive bacteria Staphylococcus aureus |
| 4.6.1.18 | more |
isoform RNase3 is bactericidal with potent activities against the gramnegative bacteria Escherichia coli and Pseudomonas aeruginosa but only mild effects against the gram-positive bacteria Staphylococcus aureus |
| 4.6.1.18 | more |
the enzyme degrades single-stranded and/or double-stranded RNA |
| 4.6.1.18 | RNA + H2O |
- |
| 4.6.1.18 | RNA + H2O |
endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA |
