EC Number   |
Natural Substrates |
|---|
   4.6.1.13 | 1-phosphatidyl-1D-myo-inositol |
natural substrate |
| 4.6.1.13 | 1-phosphatidyl-1D-myo-inositol |
natural aggregate substrate, PI-PLC is a virulence factor of the animal and human pathogen |
| 4.6.1.13 | 1-phosphatidyl-1D-myo-inositol |
- |
| 4.6.1.13 | more |
Bacillus anthracis enzyme down-modulates dendritic cell function und T cell responses, possibly by cleaving GPI-anchored proteins important for TLR-mediated dendritic cell activation |
| 4.6.1.13 | more |
Listeria monocytogenes phosphatidylinositol-specific phospholipase C is an important determinant of Listeria monocytogenes pathogenesis by absence of the Vb beta-strand, thus leading to greatly reduced activity on GPI-anchored proteins |
| 4.6.1.13 | more |
the enzyme activates a host protein kinase C cascade which promotes escape of the bacterium from a macrophage-like cell phagosome |
| 4.6.1.13 | more |
the enzyme contributes to listerial infection of epithelial cells and macrophages as a virulence factor cooperating with other factors such as listeriolysin O and phosphatidylcholine-preferring phospholipase C |
| 4.6.1.13 | more |
the enzyme exhibits cytotoxicity against some cultivated cells |
| 4.6.1.13 | more |
the enzyme may have a role in Bacillus anthracis pathogenesis |
