EC Number   |
Natural Substrates |
|---|
   4.1.99.13 | (6-4) photoproduct (in DNA) |
- |
| 4.1.99.13 | (6-4) photoproduct (in DNA) |
(6-4) photolyases repair (6-4) pyrimidine-pyrimidone photoproducts. CmPHR1 exhibits a repair activity of both (6-4)-ssDNA and (6-4)-dsDNA. Cryptochromes CmPHR2 and CmPHR5 show CPD repair activity only on ssDNA, and have no repair activity when CPD-damaged dsDNA is used as a substrate |
| 4.1.99.13 | (6-4) photoproduct (in DNA) |
PhrB is active with ssDNA and dsDNA TT (6-4) photoproducts |
| 4.1.99.13 | cyclobutadipyrimidine in DNA |
- |
| 4.1.99.13 | more |
cyclobutane pyrimidine dimer-photolyase (EC 4.1.99.3) or 6-4PP-photolyase are able to prevent UV-induced apoptosis in cells deficient for nucleotide excision repair to a similar extent, while in nucleotide excision repair-proficient cells UV-induced apoptosis is prevented only by cyclobutane pyrimidine dimer-photolyase, with no effects observed when pyrimidine-(6-4)-pyrimidone photoproducts are removed by the specific photolyase. Both cyclobutane pyrimidine dimers and pyrimidine-(6-4)-pyrimidone photoproducts contribute to UV-induced apoptosis in nucleotide excision repair-deficient cells, while in nucleotide excision repair-proficient cells, cyclobutane pyrimidine dimers are the only lesions responsible for UV-killing, probably due to the rapid repair of pyrimidine-(6-4)-pyrimidone photoproducts by nucleotide excision repair |
| 4.1.99.13 | more |
the repair function requires to transfer a functional group (OH in the case T(6-4)T) from the 5' to the 3' base, in addition to intradimer bond cleavage |
| 4.1.99.13 | T(6-4)T photoproduct (in DNA) |
- |
