EC Number   |
Natural Substrates |
|---|
   3.6.5.1 | GTP + H2O |
- |
| 3.6.5.1 | GTP + H2O |
Gi1alpha, Gi2alpha and Gi3alpha are capable of preventing stimulation of adenylate cyclase by the alpha2A-adrenoceptor |
| 3.6.5.1 | GTP + H2O |
taste-specific G protein, gustducin |
| 3.6.5.1 | GTP + H2O |
photoreceptor G protein |
| 3.6.5.1 | GTP + H2O |
Gi: the G protein that mediates inhibition of adenylate cyclase |
| 3.6.5.1 | GTP + H2O |
intrinsic GTPase activity of transducin controls inactivation of the effector enzyme, cGMP phosphodiesterase during turnoff of the visual signal |
| 3.6.5.1 | GTP + H2O |
GTPase that functions as a component of the rhodopsin-linked, light-activated phosphodiesterase system |
| 3.6.5.1 | GTP + H2O |
cycle of G protein activation and deactivation that transmits a signal from receptor to effector: when GDP is bound the alpha subunit associated with the betagamma subunit to form an inactive heterotrimer that binds to the receptor. Both alpha and betagamma subunits can bind to the receptor. When a chemical or physical signal stimulates the receptor, the receptor becomes activated and changes its conformation. The GDP-ligated alpha-subunit responds with a conformational change that decreases GDP affinity, so that GDP is released. Leaving GDP is replaced by GTP. Once ATP is bound, the alpha subunit assumes its activated conformation and dissociates both from the receptor and from betagamma. The activated state lasts until the GTP is hydrolyzed to GDP by the intrinsic GTPase activity of the alpha-subunit. Once GTP is cleaved to GDP, the alpha and betagamma subunits reassociate, become inactive, and return to the receptor. The free alpha and betagamma subunits each activate target effectors. Galphas and Galphaolf, stimulate adenylyl cyclase and regulate Ca2+ channels. Galphai-1, Galphai-2, Galphai-3, Galphao, Galphat-1, Galphat-2, Galphagust and Galphaz inhibit adenylyl cyclase, regulate K+ and Ca2+ channels, and activate cGMP phosphodiesterase. Galphaq, Galpha11, Galpha14, Galppha15 and Galpha16 activate phospholipase C. Galpha12 and Galpha13 regulate Na/K+ exchange. The betagamma subunit is a positive regulator of K+ channels, adenylyl cyclase, phospholipase Cbeta, phospholipase A2, phosphoinositide 3-kinase and beta-adrenergic receptor kinase |
| 3.6.5.1 | GTP + H2O |
Gq/11 is the physiological regulator of phospholipase C-beta1 |
| 3.6.5.1 | GTP + H2O |
Galpha subunits can regulate intracellular effectors, such as adenylyl cyclase, phospholipase Cbeta, K+ and Ca+ channels, and cyclic GMP phosphodiesterase |
