EC Number   |
Natural Substrates |
|---|
   3.5.3.15 | fibrin L-arginine + H2O |
citrullinated fibrin is a potential antigen of rheumatoid arthritis |
| 3.5.3.15 | fibrinogen-L-arginine + H2O |
PAD4, involvement in rheumatoid arthritis |
| 3.5.3.15 | filaggrin-L-arginine + H2O |
PAD4, involvement in rheumatoid arthritis |
| 3.5.3.15 | glial fibrillary acidic protein L-arginine + H2O |
- |
| 3.5.3.15 | glial fibrillary acidic protein-L-arginine + H2O |
PAD2, involvement in Alzheimer's diease |
| 3.5.3.15 | glycogen phosphorylase b + H2O |
specific deimination by peptidylarginine deiminase has a pronounced effect on the binding of some allosteric effectors with the enzyme and hampers the association of phosphorylase b dimers into tetramers in the presence of AMP |
| 3.5.3.15 | histone H2A-L-arginine + H2O |
PAD4, involvement in rheumatoid arthritis |
| 3.5.3.15 | histone H3-L-Arg + H2O |
PADI4 is a histone H3-specific arginine deiminase. Deimination is a mechanism for antagonizing the transcriptional induction mediated by arginine methylation |
| 3.5.3.15 | histone H3-L-arginine + H2O |
- |
| 3.5.3.15 | histone H3-L-arginine + H2O |
PAD4, involvement in rheumatoid arthritis |
