EC Number   |
Natural Substrates |
|---|
   3.5.1.98 | alpha-tubulin + H2O |
splicing variant HDAC6p114 is intact in its deacetylase activity against a-tubulin |
| 3.5.1.98 | alpha-tubulin + H2O |
- |
| 3.5.1.98 | more |
conserved mechanism of histone deacetylase repression of some secondary metabolite gene clusters |
| 3.5.1.98 | more |
histone deacetylases regulate the expression of HoxA9, which acts as a master switch to regulate the expression of prototypical endothelial-committed genes such as endothelial nitric oxide synthase, VE-cadherin, VEGF-R2, and mediates the shear stress-induced maturation of endothelial cells |
| 3.5.1.98 | more |
isoform HDAC4 is an essential regulator of myofibroblastic differentiation |
| 3.5.1.98 | more |
isoforms HDAC1 and HDAC2 are associated in vivo, complex is able to deacetylate all four core histones in vitro |
| 3.5.1.98 | more |
acetylation of histone core proteins is regulated by HDAC, H3K9-K14 deacetylation is mediated, at least in part, by HDAC 11 |
| 3.5.1.98 | more |
deacetylation of tubulin |
| 3.5.1.98 | more |
HDAC6 deacetylases tubulins, best noted substrate is beta-tubulin |
| 3.5.1.98 | more |
HDACs catalyse the removal of acetyl groups from e-N-acetylated lysine residues of various protein substrates |
