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Results 1 - 10 of 11

EC Number	Natural Substrates	Commentary (Nat. Sub.)
3.4.24.B12	aggrecan + H2O	-
3.4.24.B12	aggrecan + H2O	cleavage site is Glu373-Ala374
3.4.24.B12	aggrecan + H2O	degradation of cartilage matrix
3.4.24.B12	aggrecan + H2O	enzyme may play a role in cartilage breakdown
3.4.24.B12	aggrecan + H2O	ADAMTS-4 and ADAMTS-5 are the proteases responsible for the endogenous aggrecanase activity observed in IL-1beta stimulated bovine cartilage
3.4.24.B12	aggrecan + H2O	aggrecan cleavage by a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 5 (ADAMTS-5) is crucial for the breakdown of cartilage matrix during osteoarthritis, a degenerative joint disease that leads to the progressive destruction of articular structures
3.4.24.B12	aggrecan + H2O	cleavage at Glu373-Ala374
3.4.24.B12	aggrecan + H2O	cleavage site is Glu373-Ala374, reaction is relevant to cartilage degeneration in inflammatory joint diseases
3.4.24.B12	proteins + H2O	-
3.4.24.B12	versican + H2O	-

Results 1 - 10 of 11

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Release 2023.1 (January 2023)