EC Number   |
Natural Substrates |
|---|
   3.4.24.81 | alcadein + H2O |
- |
| 3.4.24.81 | amyloid precursor protein + H2O |
ADAM10 plays a central role in the developing brain by controlling mainly Notch-dependent pathways but likely also by reducing surface shedding of other neuronal membrane proteins including amyloid precursor protein |
| 3.4.24.81 | amyloid precursor protein + H2O |
cleaves amyloid precursor protein in its transmembrane region alpha-secretase activity |
| 3.4.24.81 | amyloid precursor protein + H2O |
tetraspanin12 associates with mature ADAM10, promotes ADAM10 maturation, and enhances ADAM10 dependent cleavage of amyloid precursor protein |
| 3.4.24.81 | annexin A1 + H2O |
- |
| 3.4.24.81 | annexin A1 + H2O |
ADAM10 cleaves within the N-terminal domain after Phe7, cleavage occurs on the outer cell surface during secondary but not primary necrosis |
| 3.4.24.81 | beta-amyloid precursor protein |
- |
| 3.4.24.81 | beta-amyloid precursor protein |
A172 cell line has alpha-secretase activity |
| 3.4.24.81 | beta-amyloid precursor protein |
LoVo cell line overexpressing ADAM10 secreted a 185% of sAPP-alpha over control values |
| 3.4.24.81 | beta-amyloid precursor protein |
platelet and cerebrospinal fluid have lower levels of alpha-APP in Alzheimer patients |
