EC Number   |
Natural Substrates |
|---|
   3.4.24.74 | actin + H2O |
- |
| 3.4.24.74 | E-cadherin + H2O |
- |
| 3.4.24.74 | E-cadherin + H2O |
cleavage of the zonula adherens protein |
| 3.4.24.74 | E-cadherin + H2O |
the enzyme hydrolyzes the extracellular domain of several protein substrate, e.g. of E-cadherin to interrupt the intercellular adhesion increasing the permeability of the epithelium, and causing intracellular redistribution of actin with morphologic changes and release of beta-catenin |
| 3.4.24.74 | E-cadherin + H2O |
in vivo substrate |
| 3.4.24.74 | E-cadherin + H2O |
the enzyme cleaves the extracellular domain of E-cadherin. Its cleavage then releases beta-catenin associated with the cytoplasmic domain of E-cadherin |
| 3.4.24.74 | Fibrinogen + H2O |
- |
| 3.4.24.74 | more |
the cytopathic effect of the enzyme is only seen in cells that can form tight junction and polarized monolayers, the enzyme affects the barrier function of the epithelium and decreases the transpithelial electrical resistance of monolayers, overview, the enzyme stimulates the recruitment of polymorphs to the lamina propria and seceretion of interleukin-8, epithelial neutrophil-activating peptide-78, and growth-related oncogene-alpha from colonocytes, overview |
| 3.4.24.74 | more |
the cytopathic effect of the enzyme is only seen in cells that can form tight junction and polarized monolayers, the enzyme affects the barrier function of the epithelium and decreases the transpithelial electrical resistance of monolayers, overview, the enzyme stimulates the recruitment of polymorphs to the lamina propria and secretion of interleukin-8, epithelial neutrophil-activating peptide-78, and growth-related oncogene-alpha from colonocytes, overview |
| 3.4.24.74 | more |
the enterotoxin has cytotoxic activity, however strains isolated from stool samples of calves with diarrhea contain the gene bft, but do not show cytotoxic activity against HT29 cells, overview |
