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Results 1 - 10 of 22

EC Number	Natural Substrates	Commentary (Nat. Sub.)
3.4.24.73	collagen XII + H2O	-
3.4.24.73	collagen XIV + H2O	-
3.4.24.73	Fibrinogen + H2O	-
3.4.24.73	Laminin + H2O	degradation
3.4.24.73	matrilin 1 + H2O	-
3.4.24.73	matrilin 3 + H2O	-
3.4.24.73	matrilin 4 + H2O	-
3.4.24.73	more	main hemorrhagic metalloproteinase in Bothrops jararaca venom
3.4.24.73	more	jararhagin blocks type I collagen-induced platelet aggregation by binding to the alpha2beta1 integrin and inhibiting collagen-mediated intracellular signaling events, in contrast to observation in platelets enzyme binding to the integrin receptor alpha2beta1 in fibroblasts produces collagen-like cell signaling events such as up-regulation of matrix metalloproteinase-1 and membrane-type matrix metalloproteinase-1, in fibroblasts enzyme functions as a collagen-mimetic substrate that binds to and activates integrins
3.4.24.73	more	low doses of the toxin jararhagin induce interstitial edema and increase the metabolic rate and red blood cells in Swiss mice, histology of lungs and kidney, overview, at high doses it causes hemorrhage, inflammation, necrosis and edema

Results 1 - 10 of 22

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Release 2023.1 (January 2023)